{"id":19689,"date":"2026-01-14T10:55:04","date_gmt":"2026-01-14T10:55:04","guid":{"rendered":"https:\/\/p-bio.org\/noticias\/chrysea-announces-collaboration-with-mount-sinai-to-study-sprevive-dose-levels-in-humans\/"},"modified":"2026-03-12T15:37:44","modified_gmt":"2026-03-12T15:37:44","slug":"chrysea-announces-collaboration-with-mount-sinai-to-study-sprevive-dose-levels-in-humans","status":"publish","type":"noticias","link":"https:\/\/p-bio.org\/en\/news\/chrysea-announces-collaboration-with-mount-sinai-to-study-sprevive-dose-levels-in-humans\/","title":{"rendered":"Chrysea Announces Collaboration with Mount Sinai to Study Sprevive\u00ae Dose Levels in Humans"},"content":{"rendered":"\t\t
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\u2013 An early-phase clinical study designed to characterise bio-effective dosing in immune and <\/i><\/span>metabolic biomarkers<\/i><\/h3>

\u2013 <\/i>Investigation of dose\u2013response relationships in biological markers related to immune and <\/i><\/span>metabolic function.<\/i><\/h3>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Chrysea Labs<\/a> has announced a collaboration with Mount Sinai researchers who are Top 40 <\/span>Milestone Award winners in the XPRIZE Healthspan, a $101 million global competition focused on <\/span>advancing research on ageing and healthspan-related science.<\/span><\/h3>

Miriam Merad, MD, PhD and Thomas Marron, MD, PhD are leading an early-phase, dose-escalation <\/span>clinical study designed to evaluate bio-effective dose levels of Chrysea\u2019s Sprevive\u00ae – a pure <\/span> spermidine formulation, in immune and metabolic markers. The study is being conducted at the Atria <\/span>Health and Research Institute in New York City, with Dr. David Dodick, Dr. Gregory Poland, and Dr. Louis <\/span>DePalo serving as co-investigators on the trial.<\/span><\/h3>

Dr. Merad leads the Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, <\/span>which is focused on translating immunology discoveries into clinical research. Dr. Merad said: \u201cOur <\/span>goal is to develop practical, science-driven approaches to better understand immune ageing and <\/span>the biology of chronic, low-grade inflammation associated with ageing.\u201d<\/span><\/h3>

Dr. Marron, Director of the Early Phase Trials Unit at The Tisch Cancer Institute and Professor of <\/span>Immunology and Immunotherapy at the Icahn School of Medicine at Mount Sinai, said: \u201cWe are <\/span>excited to initiate this clinical study in partnership with Chrysea to help characterise dose\u2013<\/span>response relationships of spermidine using biomarkers relevant to immune and metabolic <\/span>function.\u201d<\/span><\/h3>

Dr. PatrickKeohane, Chief Medical Officer at Chrysea, said: \u201cChrysea Labs welcomes the opportunity <\/span>to collaborate with a world-leading clinical research centre to generate new human data and <\/span>advance the scientific understanding of dose optimisation in the context of ageing biology.\u201d<\/span><\/h3>

Building on this collaboration, Chrysea again reaffirms its commitment to advancing longevity <\/span>biotechnology through scientific rigour, clinical discipline, and translational research. By grounding <\/span>product development in human biology, dose-response evidence, and well-designed clinical studies, <\/span>Chrysea aims to help bridge the gap between longevity science and clinical reality while supporting <\/span>the development of truly first-in-class interventions in the field.<\/span><\/h3>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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About the Icahn School of Medicine at Mount Sinai<\/span><\/h3>

<\/span>The Icahn School of Medicine at Mount Sinai is an internationally renowned centre for research, <\/span>education, and clinical care. As the academic heart of the Mount Sinai Health System\u2014one of the <\/span>largest in the U.S.\u2014it serves New York City\u2019s diverse population through seven member hospitals.
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Ranked 11th nationwide in NIH funding and placing in the 99th percentile for research dollars per <\/span>investigator, the school is a powerhouse of translational medicine. It supports over 4,500 scientists <\/span>and clinicians across dozens of multidisciplinary institutes.
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With the nation’s largest graduate medical education program, it trains more than 4,300 students, <\/span>residents, and fellows. Through Mount Sinai Innovation Partners (MSIP), the institution ensures medical <\/span>breakthroughs are rapidly commercialized and transitioned into real-world clinical applications.<\/span><\/h3>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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About Chrysea<\/span><\/h3>

Chrysea is a biotechnology company revolutionizing the healthcare and wellness industry with <\/span>precision healthy-lifespan interventions. Leveraging tools of Synthetic Biology and Data Analytics we <\/span>have unlocked the potential to manufacture products of unparalleled purity at scale, introducing <\/span>solutions previously inaccessible to industry. Our approach integrates these advanced tools <\/span>seamlessly into our operations, enabling us to establish a vertically integrate, sustainable business <\/span>model that spans from laboratory research, directly to the consumer. Chrysea\u2019s products are backed <\/span>by rigorous science-backed clinical research, ensuring pure, safe, functional brands that consumers <\/span>can trust.<\/span><\/h3>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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P-BIO<\/b><\/h3>

January 14, 2026<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Chrysea Labs today announced a collaboration with Mount Sinai researchers who are Top 40
\nMilestone Award winners in the XPRIZE Healthspan, a $101 million global competition focused on
\nadvancing research on ageing and healthspan-related science.<\/p>\n","protected":false},"featured_media":17087,"template":"","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"footnotes":""},"categoria":[249,291],"class_list":["post-19689","noticias","type-noticias","status-publish","has-post-thumbnail","hentry","categoria-associados","categoria-chrysea"],"_links":{"self":[{"href":"https:\/\/p-bio.org\/en\/wp-json\/wp\/v2\/noticias\/19689","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/p-bio.org\/en\/wp-json\/wp\/v2\/noticias"}],"about":[{"href":"https:\/\/p-bio.org\/en\/wp-json\/wp\/v2\/types\/noticias"}],"version-history":[{"count":1,"href":"https:\/\/p-bio.org\/en\/wp-json\/wp\/v2\/noticias\/19689\/revisions"}],"predecessor-version":[{"id":19690,"href":"https:\/\/p-bio.org\/en\/wp-json\/wp\/v2\/noticias\/19689\/revisions\/19690"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/p-bio.org\/en\/wp-json\/wp\/v2\/media\/17087"}],"wp:attachment":[{"href":"https:\/\/p-bio.org\/en\/wp-json\/wp\/v2\/media?parent=19689"}],"wp:term":[{"taxonomy":"categoria","embeddable":true,"href":"https:\/\/p-bio.org\/en\/wp-json\/wp\/v2\/categoria?post=19689"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}